Summary information and primary citation
- PDB-id
-
1pzu;
DSSR-derived features in text and
JSON formats
- Class
- transcription-DNA
- Method
- X-ray (3.1 Å)
- Summary
- An asymmetric nfat1-rhr homodimer on a
pseudo-palindromic, kappa-b site
- Reference
-
Jin L, Sliz P, Chen L, Macian F, Rao A, Hogan PG,
Harrison SC (2003): "An
asymmetric NFAT1 dimer on a pseudo-palindromic KB-like
DNA site." Nat.Struct.Biol.,
10, 807-811. doi: 10.1038/nsb975.
- Abstract
- The crystal structure of the NFAT1 Rel homology region
(RHR) bound to a pseudo-palindromic DNA site reveals an
asymmetric dimer interaction between the RHR-C domains,
unrelated to the contact seen in Rel dimers such as NF
kappa B. Binding studies with a form of the NFAT1 RHR
defective in the dimer contact show loss of cooperativity
and demonstrate that the same interaction is present in
solution. The structure we have determined may correspond
to a functional NFAT binding mode at palindromic sites of
genes induced during the anergic response to weak TCR
signaling.
